Bcl-2 family: Life-or-death switch

被引：620

作者：

Tsujimoto, Y ^{[1
]}

Shimizu, S ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Biomed Res Ctr, Dept Med Genet,CREST,Japan Sci & Technol Corp, Osaka 5650871, Japan

来源：

FEBS LETTERS | 2000年 / 466卷 / 01期

关键词：

apoptosis; Bcl-2; mitochondrion; cytochrome c; VDAC;

D O I：

10.1016/S0014-5793(99)01761-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Bcl-2 family of proteins that consists of anti-apoptotic and pro-apoptotic members determines life-or-death of a cell by controlling the release of mitochondrial apoptogenic factors, cytochrome c and apoptosis-inducing factor (AIF), that activate downstream executional phases, including the activation of death proteases called caspases, Cytochrome c release is, thus, central to apoptotic signal transduction in mammals, making study of the mechanism for cytochrome c release a major issue. Several models for cytochrome c release have been proposed, including rupture of mitochondrial outer membrane and involvement of a specific channel. Here, we pro,ide an overview of recent findings on the role of Bcl-2 family members in the life-or-death decision of a cell. (C) 2000 Federation of European Biochemical Societies.

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页码：6 / 10

页数：5

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