Cancer chromosomes in crisis

被引：78

作者：

DePinho, RA ^{[1
]}

Polyak, K

机构：

[1] Dana Farber Canc Inst, Ctr Appl Canc Sci, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[5] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[7] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

来源：

NATURE GENETICS | 2004年 / 36卷 / 09期

关键词：

D O I：

10.1038/ng0904-932

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The benign-to-malignant transition in human breast cancer is associated with a marked increase in chromosomal aberrations. A new study suggests that telomere dysfunction and its associated bridge-fusion-breakage cycles may drive this episodic instability, thereby providing aspiring cancer cells with the multiple genetic aberrations needed to achieve a fully malignant state.

引用

页码：932 / 934

页数：4

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