Synthesis of the C31-C67 fragment of amphidinol 3

被引：41

作者：

de Vicente, Javier ^{[1
]}

Huckins, John R. ^{[1
]}

Rychnovsky, Scott D. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 43期

关键词：

Julia olefination; natural products; polyenes; polyketides; tetrahydropyran;

D O I：

10.1002/anie.200602742

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A tetrahydropyran intermediate, prepared from (-)-diethyl tartrate, was used to assemble the C31-C67 fragment of amphidinol 3. Both of the tetrahydropyran rings in the natural product were prepared from this intermediate. The polyene segment was assembled with high selectivity. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7258 / 7262

页数：5

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