Liposomes in drug delivery: progress and limitations

被引：856

作者：

Sharma, A ^{[1
]}

Sharma, US ^{[1
]}

机构：

[1] SUNY BUFFALO,DEPT PHARMACEUT,BUFFALO,NY 14260

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1997年 / 154卷 / 02期

关键词：

liposome; drug deliver; doxorubicin; amphotericin B;

D O I：

10.1016/S0378-5173(97)00135-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Liposomes are microparticulate lipoidal vesicles which are under extensive investigation as drug carriers for improving the delivery of therapeutic agents. Due to new developments in liposome technology, several liposome-based drug formulations are currently in clinical trial, and recently some of them have been approved for clinical use. Reformulation of drugs in liposomes has provided an opportunity to enhance the therapeutic indices of various agents mainly through alteration in their biodistribution. This review discusses the potential applications of liposomes in drug delivery with examples of formulations approved for clinical use: and the problems associated with further exploitation of this drug delivery system. (C) 1997 Elsevier Science B.V.

引用

页码：123 / 140

页数：18

共 73 条

[51]

OHSAWA T, 1984, CHEM PHARM BULL, V32, P2442

[52] PHOSPHOLIPID MODEL MEMBRANES .2. PERMEABILITY PROPERTIES OF HYDRATED LIQUID CRYSTALS [J].