Iridium Catalysis for C-H Bond Arylation of Heteroarenes with lodoarenes

被引：182

作者：

Join, Benoit ^{[1
,2
]}

Yamamoto, Takuya ^{[1
,2
]}

Itami, Kenichiro ^{[1
,2
]}

机构：

[1] Nagoya Univ, Dept Chem, Grad Sch Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[2] PRESTO Sci & Technol Agcy, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 20期

关键词：

biaryls; C-C coupling; heterocycles; homogeneous catalysis; iridium; CROSS-COUPLING REACTIONS; ROOM-TEMPERATURE; ARYL CHLORIDES; NITROGEN-HETEROCYCLES; N-OXIDES; FUNCTIONALIZATION; ARENES; ALKENYLATION; ACTIVATION; COMPLEX;

D O I：

10.1002/anie.200806358

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Efficient couplings using equimolar quantities of each coupling partner and multiple C - H bond arylation reactions are achieved with an Ir-based catalytic system for the C - H bond arylation of electron-rich heteroarenes with iodoarenes to construct extended π-systems. The dramatic ligand effect on reaction efficiency leads to the discovery that Crabtree's catalyst (see scheme) is the optimal catalyst precursor. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3644 / 3647

页数：4

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