RNA editing of a miRNA precursor

被引：234

作者：

Luciano, DJ ^{[1
]}

Mirsky, H ^{[1
]}

Vendetti, NJ ^{[1
]}

Maas, S ^{[1
]}

机构：

[1] Lehigh Univ, Dept Biol Sci, Bethlehem, PA 18015 USA

来源：

RNA | 2004年 / 10卷 / 08期

关键词：

RNA editing; miRNA; inosine; pri-miRNA; adenosine deaminase; ADAR;

D O I：

10.1261/rna.7350304

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Micro RNAs comprise a large family of small, functional RNAs with important roles in the regulation of protein coding genes in animals and plants. Here we show that human and mouse miRNA22 precursor molecules are subject to posttranscriptional modification by A-to-I RNA editing in vivo. The observed editing events are predicted to have significant implications for the biogenesis and function of miRNA22 and might point toward a more general role for RNA editing in the regulation of miRNA gene expression.

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收藏

页码：1174 / 1177

页数：4

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