Aza-annulation as a versatile approach to the synthesis of non-benzodiazepene compounds for the treatment of sleep disorders

被引：24

作者：

Benovsky, P

Stille, JR

机构：

[1] ELI LILLY & CO,LILLY RES LABS,CHEM PROC RES & DEV,INDIANAPOLIS,IN 46285

[2] MICHIGAN STATE UNIV,DEPT CHEM,E LANSING,MI 48824

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 49期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)10297-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The aza-annulation of enamino ester substrates has been demonstrated as an efficient alternative to the syntheses of non-benzodiazepine sleep inducers. Enamino ester substrates derived from aryl, thiophene, and indole functionality were prepared from the corresponding ethyl amines by isothiocyanate formation followed by acid catalyzed cyclization. (C) 1997 Elsevier Science Ltd.

引用

页码：8475 / 8478

页数：4

共 31 条

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