Molecular programming of stem cells into mesodiencephalic dopaminergic neurons

被引：41

作者：

Burbach, J. Peter H. ^{[1
]}

Smidt, Marten P. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Pharmacol & Anat, Rudolf Magnus Inst Neurosci, NL-3508 AB Utrecht, Netherlands

来源：

TRENDS IN NEUROSCIENCES | 2006年 / 29卷 / 11期

关键词：

D O I：

10.1016/j.tins.2006.09.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In a screen for homeobox transcription factors expressed in the embryonic ventral midbrain, Andersson et al. recently identified Lmx1a and Msx1. Using in ovo electroporation in chick embryos, they showed that these factors are crucial for initiating the differentiation of neuroepithelial progenitor neurons into mesodiencephalic dopaminergic (mdDA) neurons. Lmx1a also initiated a developmental program that drove an mdDA phenotype in mouse embryonic stem cells. This indicates that these factors can be exploited in cell-replacement strategies for treatment of Parkinson's disease.

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页码：601 / 603

页数：3

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