Functional aspects of the Leishmania donovani lipophosphoglycan during macrophage infection

被引：48

作者：

Descoteaux, A

Turco, SJ

机构：

[1] Univ Quebec, Inst Armand Frappier, INRS, Laval, PQ H7V 1B7, Canada

[2] Univ Kentucky, Med Ctr, Dept Biochem, Lexington, KY 40502 USA

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 09期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

Leishmania; lipophosphoglycan; protein kinase C;

D O I：

10.1016/S1286-4579(02)01624-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The most abundant surface glycoconjugate of the Leishmania promastigotes is lipophosphoglycan, a glycosylphosphatidyl-inositol-anchored polymer of the repeating disaccharide-phosphate Gal(beta1,4)Manalpha1-PO4 unit. This complex molecule possesses properties that contribute to the ability of Leishmania to modulate macrophage signaling pathways during the initiation of infection. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

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收藏

页码：975 / 981

页数：7

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