Physiology of GDF9 and BMP15 signalling molecules

被引：115

作者：

Juengel, JL

Bodensteiner, KJ

Heath, DA

Hudson, NL

Moeller, CL

Smith, P

Galloway, SM

Davis, GH

Sawyer, HR

McNatty, KP

机构：

[1] AgResearch, Wallaceville Anim Res Ctr, Upper Hutt, New Zealand

[2] St Lawrence Univ, Dept Biol, Canton, NY 13617 USA

[3] Colorado State Univ, Anim Reprod & Biotechnol Lab, Ft Collins, CO 80523 USA

[4] Univ Otago, Dept Biochem, Mol Biol Unit, Dunedin, New Zealand

[5] AgResearch, Invermay Agr Ctr, Dunedin, New Zealand

[6] Univ Wyoming, Coll Hlth Sci, Laramie, WY 82071 USA

来源：

ANIMAL REPRODUCTION SCIENCE | 2004年 / 82-3卷

关键词：

transforming growth factor-beta superfamily; GDF9; BMP15; follicular growth; ovulation rate; ovary;

D O I：

10.1016/j.anireprosci.2004.04.021

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Two related oocyte-derived members of the transforming growth factor-beta (TGF-beta) superfamily, namely growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15, also known as GDF9B), have recently been shown to be essential for ovarian follicular growth. In addition, both proteins have been shown to regulate ovulation rate in sheep, and although it is evident that these growth factors interact both with one another and with other intra- and extra-ovarian factors, the precise mechanisms by which they influence follicular growth and ovulation rate have not been thoroughly elucidated. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：447 / 460

页数：14

共 62 条

[61] Growth differentiation factor-9 inhibits 3′5′-adenosine monophosphate-stimulated steroidogenesis in human granulosa and theca cells [J].