The Involvement and Therapy Target of Immune Cells After Ischemic Stroke

被引：247

作者：

Jian, Zhihong ^{[1
]}

Liu, Rui ^{[2
,3
]}

Zhu, Xiqun ^{[1
]}

Smerin, Daniel ^{[4
]}

Zhong, Yi ^{[1
]}

Gu, Lijuan ^{[5
]}

Fang, Weirong ^{[2
]}

Xiong, Xiaoxing ^{[1
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Neurosurg, Wuhan, Hubei, Peoples R China

[2] China Pharmaceut Univ, Sch Basic Med Sci & Clin Pharm, State Key Lab Nat Med, Nanjing, Jiangsu, Peoples R China

[3] Shandong Inst Food & Drug Control, Dept Pharmacol & Toxicol, Jinan, Shandong, Peoples R China

[4] Univ Cent Florida, Coll Med, Dept Neurosurg, Orlando, FL 32816 USA

[5] Wuhan Univ, Renmin Hosp, Cent Lab, Wuhan, Hubei, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

基金：

中国国家自然科学基金;

关键词：

ischemic stroke; immune cell; macrophage; microglia; inflammation; REGULATORY T-CELLS; FOCAL CEREBRAL-ISCHEMIA; MICROGLIA/MACROPHAGE POLARIZATION DYNAMICS; MONOCYTE-DERIVED MACROPHAGES; LIMIT CNS INFLAMMATION; NF-KAPPA-B; DENDRITIC CELLS; IN-VIVO; NEUTROPHIL RECRUITMENT; ACTIVATED MICROGLIA;

D O I：

10.3389/fimmu.2019.02167

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

After ischemic stroke, the integrity of the blood-brain barrier is compromised. Peripheral immune cells, including neutrophils, T cells, B cells, dendritic cells, and macrophages, infiltrate into the ischemic brain tissue and play an important role in regulating the progression of ischemic brain injury. In this review, we will discuss the role of different immune cells after stroke in the secondary inflammatory reaction and focus on the phenotypes and functions of macrophages in ischemic stroke, as well as briefly introduce the anti-ischemic stroke therapy targeting macrophages.

引用

页数：15

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