Autoimmunity - Decoy receptors thwart B cells

被引：11

作者：

Ware, CF ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Mol Immunol, San Diego, CA 92121 USA

来源：

NATURE | 2000年 / 404卷 / 6781期

关键词：

D O I：

10.1038/35010263

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lupus erythematosus is a debilitating autoimmune disease, a feature of which is the presence of hyperactive B cells. The discovery of a new pathway that stimulates B-cell proliferation provides insight into the biology of this disease, and allowed the construction of antagonists of the pathway that halt disease progression in mice.

引用

页码：949 / 950

页数：3

共 12 条

[1] A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
Chan, OTM
Hannum, LG
Haberman, AM
Madaio, MP
Shlomchik, MJ
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (10) : 1639 - 1647
[2] TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
Gross, JA
Johnston, J
Mudri, S
Enselman, R
Dillon, SR
Madden, K
Xu, WF
Parrish-Novak, J
Foster, D
Lofton-Day, C
Moore, M
Littau, A
Grossman, A
Haugen, H
Foley, K
Blumberg, H
Harrison, K
Kindsvogel, W
Clegg, CH
[J]. NATURE, 2000, 404 (6781) : 995 - 999
[3] Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice
Khare, SD
Sarosi, I
Xia, XZ
McCabe, S
Miner, K
Solovyev, I
Hawkins, N
Kelley, M
Chang, D
Van, G
Ross, L
Delaney, J
Wang, L
Lacey, D
Boyle, WJ
Hsu, HL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) : 3370 - 3375
[4] Systemic lupus erythematosus
Kotzin, BL
[J]. CELL, 1996, 85 (03) : 303 - 306
[5] Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
Mackay, F
Woodcock, SA
Lawton, P
Ambrose, C
Baetscher, M
Schneider, P
Tschopp, J
Browning, JL
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (11) : 1697 - 1710
[6] The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily
Madry, C
Laabi, Y
Callebaut, I
Roussel, J
Hatzoglou, A
Le Coniat, M
Mornon, JP
Berger, R
Tsapis, A
[J]. INTERNATIONAL IMMUNOLOGY, 1998, 10 (11) : 1693 - 1702
[7] BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator
Moore, PA
Belvedere, O
Orr, A
Pieri, K
LaFleur, DW
Feng, P
Soppet, D
Charters, M
Gentz, R
Parmelee, D
Li, YL
Galperina, O
Giri, J
Roschke, V
Nardelli, B
Carrell, J
Sosnovtseva, S
Greenfield, W
Ruben, SM
Olsen, HS
Fikes, J
Hilbert, DM
[J]. SCIENCE, 1999, 285 (5425) : 260 - 263
[8] Susceptibility to lupus nephritis in the NZB/W model system
Morel, L
Wakeland, EK
[J]. CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (06) : 718 - 725
[9] Identification and characterization of a novel cytokine, THANK, a (T)under-barNF (H)under-baromologue that activates (A)under-barpoptosis, nuclear factor-κB, and c-Jun NH2-terminal (K)under-barinase
Mukhopadhyay, A
Ni, J
Zhai, YF
Yu, GL
Aggarwal, BB
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (23) : 15978 - 15981
[10] Nagata S, 1994, Semin Immunol, V6, P3, DOI 10.1006/smim.1994.1002

← 1 2 →