Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis

被引：95

作者：

Gottsch, M. L.

Clifton, D. K.

Steiner, R. A.

机构：

[1] Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA

[2] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Biol, Seattle, WA 98195 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2006年 / 254卷

关键词：

kisspeptins; gonadotropin-releasing hormone; neuroendocrine reproductive axis;

D O I：

10.1016/j.mce.2006.04.030

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Kisspeptins. which are products of the Kiss1 gene, and their receptor, GPR54, have emerged as key players in the regulation of gonadotropin-releasing hormone (GnRH) secretion. Mutations or targeted deletions of GPR54 produce isolated hypogonadotropic hypogonadism in humans and mice, indicating that signaling through this receptor is a prerequisite for sexual maturation. Centrally administered kisspeptins stimulate GnRH and Gonadotropin secretion in prepubertal and adult animals. Kisspeptin-expressing neurons are direct targets for the negative and positive feedback actions of sex steroids, which differentially regulate the expression of KiSS-1 mRNA in various regions of the forebrain. This review highlights what is currently known about kisspeptin-GPR54 signaling in the regulation of the neuroendocrine reproductive axis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：91 / 96

页数：6

共 65 条

[1]

Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other Gq-coupled receptors [J].