Lessons learned in the use of volumetric MRI in therapeutic trials in Alzheimer's disease: The Alzhemedtm (Tramiprosate) experience

被引：27

作者：

Saumier, D. ^{[1
]}

Aisen, P. S. ^{[2
]}

Gauthier, S. ^{[3
]}

Vellas, B. ^{[4
]}

Ferris, S. H. ^{[5
,6
]}

Duong, A. ^{[1
]}

Suhy, J. ^{[7
]}

Oh, J. ^{[7
]}

Lau, W. ^{[7
]}

Garceau, D. ^{[8
]}

Haine, D. ^{[9
]}

Sampalis, J. ^{[10
]}

机构：

[1] BELLUS Hlth Inc, Laval, PQ H7V 4A7, Canada

[2] Univ Calif San Diego, La Jolla, CA 92093 USA

[3] McGill Ctr Studies Aging, Verdun, PQ H4H 1R3, Canada

[4] Univ Toulouse, INSERM, U558, Ctr Hosp Univ,Alzheimer Dis Res & Clin Ctr, Toulouse, France

[5] NYU, Sch Med, New York, NY 10016 USA

[6] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA

[7] Synarc Inc, San Francisco, CA 94105 USA

[8] OVOS Nat Hlth Inc, Laval, PQ H7V 4A7, Canada

[9] JSS Med Res, Westmount, PQ H3Z 1R7, Canada

[10] McGill Univ, Div Clin Epidemiol, Res Inst, McGill Univ Hlth Ctr,Royal Victoria Hosp, Montreal, PQ H3A 1A1, Canada

来源：

JOURNAL OF NUTRITION HEALTH & AGING | 2009年 / 13卷 / 04期

关键词：

HIPPOCAMPAL ATROPHY; ENTORHINAL CORTEX; AMYLOID-BETA; IMPAIRMENT; DIAGNOSIS; AMYGDALA; PHASE; AGE;

D O I：

10.1007/s12603-009-0047-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

[No abstract available]

引用

页码：370 / 372

页数：3

共 23 条

[1] A Phase II study targeting amyloid-β with 3APS in mild-to-moderate Alzheimer disease [J].

Aisen, P. S. ;

Saumier, D. ;

Briand, R. ;

Laurin, J. ;

Gervais, F. ;

Tremblay, P. ;

Garceau, D. .

NEUROLOGY, 2006, 67 (10) :1757-1763

[2]

Azzi M, 2007, 8 INT C AD PD SALZB

[3]

CANIVERI L, 2004, NEUROCHEM RES, V29, P637

[4]

Convit Antonio, 1993, Psychiatric Quarterly (New York), V64, P371, DOI 10.1007/BF01064929

[5] Early DAT is distinguished from aging by high-dimensional mapping of the hippocampus [J].

Csernansky, JG ;

Wang, L ;

Joshi, S ;

Miller, JP ;

Gado, M ;

Kido, D ;

McKeel, D ;

Morris, JC ;

Miller, MI .

NEUROLOGY, 2000, 55 (11) :1636-1643

[6] MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease [J].

Dickerson, BC ;

Goncharova, I ;

Sullivan, MP ;

Forchetti, C ;

Wilson, RS ;

Bennett, DA ;

Beckett, LA ;

deToledo-Morrell, L .

NEUROBIOLOGY OF AGING, 2001, 22 (05) :747-754

[7] Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease [J].

Du, AT ;

Schuff, N ;

Amend, D ;

Laakso, MP ;

Hsu, YY ;

Jagust, WJ ;

Yaffe, K ;

Kramer, JH ;

Reed, B ;

Norman, D ;

Chui, HC ;

Weiner, MW .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2001, 71 (04) :441-447

[8] Higher atrophy rate of entorhinal cortex than hippocampus in AD [J].

Du, AT ;

Schuff, N ;

Kramer, JH ;

Ganzer, S ;

Zhu, XP ;

Jagust, WJ ;

Miller, BL ;

Reed, BR ;

Mungas, D ;

Yaffe, K ;

Chui, HC ;

Weiner, MW .

NEUROLOGY, 2004, 62 (03) :422-427

[9] Research criteria for the diagnosis of Alzheimer"s disease: revising the NINCDS-ADRDA criteria [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Dekosky, Steven T. ;

Barberger-Gateau, Pascale ;

Cummings, Jeffrey ;

Delocourte, Andre ;

Galasko, Douglas ;

Gauthier, Serge ;

Jicha, Gregory ;

Meguro, Kenichi ;

O'Brien, John ;

Pasquier, Florence ;

Robert, Philippe ;

Rossor, Martin ;

Solloway, Steven ;

Stern, Yaakov ;

Visser, Pieter J. ;

Scheltens, Philip .

LANCET NEUROLOGY, 2007, 6 (08) :734-746

[10] The role of cerebral amyloid β accumulation in common forms of Alzheimer disease [J].

Gandy, S .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (05) :1121-1129

← 1 2 3 →