New chiral ligands derived from (S)-leucine for the enantioselective addition of diethylzinc to aldehydes

被引：29

作者：

Kawanami, Y ^{[1
]}

Mitsuie, T

Miki, M

Sakamoto, T

Nishitani, K

机构：

[1] Kagawa Univ, Dept Biochem & Food Sci, Miki, Kagawa 7610795, Japan

[2] Kagawa Univ, Dept Chem, Fac Educ, Takamatsu, Kagawa 7608522, Japan

来源：

TETRAHEDRON | 2000年 / 56卷 / 02期

关键词：

chiral ligands; enantioselective addition; (S)-leucine;

D O I：

10.1016/S0040-4020(99)00971-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of chiral beta-amino alcohols derived from (S)-leucine has been synthesized. The amino alcohol possessing a piperidine ring and a phenethyl group on the carbinol carbon atom was found to be an efficient ligand to catalyze the enantioselective addition of diethylzinc to aromatic (up to 97% ee) and aliphatic (up to 95% ee) aldehydes. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：175 / 178

页数：4

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