Natural history of the TT virus infection through follow-up of TTV DNA-positive multiple-transfused patients

被引:61
作者
Lefrère, JJ
Roudot-Thoraval, F
Lefrère, F
Kanfer, A
Mariotti, M
Lerable, J
Thauvin, M
Lefèvre, G
Rouger, P
Girot, R
机构
[1] Univ Paris 06, Inst Natl Transfus Sanguine, F-75012 Paris, France
[2] Univ Paris 06, Fac St Antoine, F-75012 Paris, France
[3] Hop Henri Mondor, Serv Sante Publ, F-94010 Creteil, France
[4] Hop Necker Enfants Malad, Hematol Serv, Paris, France
[5] Hop Tenon, Hematol Lab, F-75020 Paris, France
[6] Hop Jour Med, Biochim Lab, F-75020 Paris, France
关键词
D O I
10.1182/blood.V95.1.347.001k42_347_351
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Little is known about the natural history and the pathogenicity of the TT virus (TTV). We present our findings of a cross-sectional study based on the TTV DNA screening of 173 multiple-transfused patients and a longitudinal study based on the follow-up of TTV DNA-positive patients. Overall, 48 patients (27.7%) tested positive for TTV DNA. The influence of the number of blood donor exposures on the prevalence of bloodborne viral infection indicates that TTV, hepatitis C virus (HCV), and an RNA virus known as GB virus C/hepatitis G virus (GBV-C/HGV) share a parenteral transmission, but that TTV, in contrast to the 2 other viruses, is also transmitted by at least another efficient means. The patients having a well-defined date of TTV infection were positive for TTV DNA during a mean period of 3.1 years. A chronic infection was observed in 31 cases (86%), TTV carriage appeared clinically benign in all patients. No clinical evidence of a disease potentially linked to the TTV infection was observed in patients with TTV DNA carriage over several years. The majority of TTV carriers had no biochemical evidence of liver disease. The prevalence of elevated serum alanine aminotransferase (ALT) level was higher in the TTV DNA-positive group, even in the absence of HCV infection, but the observed peaks of ALT level were most often transient and very mild. The prevalence of TTV DNA observed in blood recipients is consistent with that of TTV infection observed in blood donors. TTV infection frequently tends to persist. (C) 2000 by The American Society of Hematology.
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页码:347 / 351
页数:5
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