Synthesis and stereochemical study of a trioxaquine prepared from cis-bicyclo[3.3.0]octane-3,7-dione

被引：9

作者：

Dechy-Cabaret, O ^{[1
]}

Robert, A ^{[1
]}

Meunier, B ^{[1
]}

机构：

[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France

来源：

COMPTES RENDUS CHIMIE | 2002年 / 5卷 / 04期

关键词：

aminoquinoline; malaria; RMN; trioxaquine; trioxane;

D O I：

10.1016/S1631-0748(02)01383-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The preparation of a modular antimalarial drug named trioxaquine containing a cis-bicyclo[3.3.0]octane-3,7-dione is reported. Two diastereomeric racemates have been separated and characterised by NMR. (C) 2002 Academie des sciences / Editions scientifiques et medicales Elsevier SAS.

引用

页码：297 / 302

页数：6

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