Synthesis and in vitro evaluation of some new pyrimidines and related condensed ring systems as potential anticancer agents

被引：22

作者：

Badawey, ESAM

机构：

[1] Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1996年 / 33卷 / 02期

关键词：

D O I：

10.1002/jhet.5570330202

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several new pyrimidines 6-11, 18-20, furo-, thieno-, and pyrrolo[2,3-d]pyrimidines 3, 8, 12, triazolo[4,3-a]pyrimidines 14, 15, 16 and tetrazolo[1,5-a]pyrimidine 17 were prepared from the known intermediate 5-(2-hydroxyethyl)-6-methyl-2-thiouracil (2). Compound 7 (4-chloro-5-(2-chloroethyl)-2-methylthio-6-methyl-pyrimidine) exhibited weak antitumor activity in vitro.

引用

页码：229 / 233

页数：5

共 9 条

[1] BENZIMIDAZOLE CONDENSED RING-SYSTEM .9. POTENTIAL ANTINEOPLASTICS - NEW SYNTHESIS OF SOME PYRIDO[1,2-A]BENZIMIDAZOLES AND RELATED DERIVATIVES [J].