Antimalarial drugs and heme in detergent micelles: An NMR study

被引：19

作者：

Casabianca, Leah B. ^{[1
]}

Kallgren, Joye B. ^{[1
]}

Natarajan, Jayakumar K. ^{[1
,2
]}

Alumasa, John N. ^{[1
]}

Roepe, Paul D. ^{[1
,2
,3
]}

Wolf, Christian ^{[1
,3
]}

de Dios, Angel C. ^{[1
,3
]}

机构：

[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA

[2] Georgetown Univ, Dept Biochem Cellular & Mol Biol, Washington, DC 20057 USA

[3] Georgetown Univ, Ctr Infect Dis, Washington, DC 20057 USA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2009年 / 103卷 / 05期

基金：

美国国家科学基金会;

关键词：

Malaria; Antimalarials; Chloroquine; Heme; Detergent; Micelle; HISTIDINE-RICH PROTEINS; BETA-HEMATIN; HEMOZOIN FORMATION; POLYMERIZATION; MALARIA; CHLOROQUINE; INHIBITION; EQUILIBRIUM; DIFFUSION; BINDING;

D O I：

10.1016/j.jinorgbio.2009.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proton nuclear magnetic resonance relaxation times were measured for the protons of micelles formed by the detergents sodium dodecyl sulfate, dodecyltrimethyl ammonium bromide, and polyethylene glycol sorbitan monolaureate in the presence of ferriprotoporphyrin IX and the antimalarial drugs chloroquine, 7-chloro-4-quinolyl 4-N,N-diethylaminobutyl sulfide, and primaquine. Diffusion coefficients were extracted from pulsed gradient NMR experiments to evaluate the degree of association of these drugs with the detergent micelles. Results indicate that at low or neutral pH when the quinolyl N is protonated, chloroquine does not associate with neutral or cationic detergent micelles. For this reason, chloroquine's interaction with heme perturbs the partitioning of heme between the aqueous medium and detergent micelles. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：745 / 748

页数：4

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