Antileishmanial activities of stearylamine-bearing liposomes

被引：40

作者：

Dey, T ^{[1
]}

Anam, K ^{[1
]}

Afrin, F ^{[1
]}

Ali, N ^{[1
]}

机构：

[1] Indian Inst Chem Biol, Leishmania Div, Calcutta 700032, W Bengal, India

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 06期

关键词：

D O I：

10.1128/AAC.44.6.1739-1742.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Here we report the activity of liposomes comprising egg phosphatidylcholine (PC) and stearylamine (SA) against Leishmania donovani parasites. Both promastigotes and intracellular amastigotes in vitro and in vivo were susceptible to SA-PC liposomes. A single dose of 55 mg of SA-PC liposomes/animal could significantly reduce the hepatic parasite burden by 85 and 68% against recent and established experimental visceral leishmaniasis, respectively, suggesting their strong therapeutic potential.

引用

页码：1739 / 1742

页数：4

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