Synthesis and antibacterial activity of lipophilic carbapenems with anti-MRSA activity

被引：8

作者：

Arnould, JC ^{[1
]}

Illingworth, RN ^{[1
]}

Nichols, WW ^{[1
]}

Wilson, RG ^{[1
]}

机构：

[1] ZENECA PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 20期

关键词：

D O I：

10.1016/0960-894X(96)00450-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of sulphur-linked and carbon-linked lipophilic carbapenems has been prepared and evaluated for antibacterial activity in vitro and in vivo and for affinity for PBP2' of Staphylococcus aureus. Potent activity in vitro against methicillin-resistant S. aureus and methicillin-resistant coagulase negative staphylococci was observed despite IC50 values for PBP2' being higher than the MIC. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：2449 / 2454

页数：6

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