Organocatalysis mediated by (thio)urea derivatives

被引：838

作者：

Connon, Stephen J. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2006年 / 12卷 / 21期

关键词：

asymmetric catalysis; hydrogen bonding; organocatalysis; thiourea; urea;

D O I：

10.1002/chem.200501076

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Over the last decade the potential for N,N-dialkyl(thio)urea derivatives to serve as active metal-free organocatalysts for a wide range of synthetically useful reactions susceptible to the influence of general acid catalysis has begun to be realised. This article charts the development of these catalysts (with emphasis on the design principles involved), from early "proof-of-concept" materials to contemporary active chiral (bifunctional) promoters of highly selective asymmetr.c transformations.

引用

页码：5418 / 5427

页数：10

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