Antimalarials from nature

被引：322

作者：

Kaur, Kirandeep ^{[1
]}

Jain, Meenakshi ^{[1
]}

Kaur, Tarandeep ^{[1
]}

Jain, Rahul ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Sas Nagar 160062, Punjab, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 09期

关键词：

Malaria; Antimalarials; Natural products; Nature based antimalarials; Semisynthetic antimalarials; VITRO ANTIPLASMODIAL ACTIVITY; PARASITE PLASMODIUM-FALCIPARUM; ENOYL-ACP REDUCTASE; INTRAERYTHROCYTIC MALARIA PARASITE; TANZANIAN MEDICINAL-PLANT; IN-VITRO; NAPHTHYLISOQUINOLINE ALKALOIDS; STRYCHNOS-ICAJA; SESQUITERPENE LACTONES; ANTIPARASITIC ACTIVITY;

D O I：

10.1016/j.bmc.2009.02.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Malaria is a major public health problem mainly due to the development of resistance by the most lethal causative parasitic species, Plasmodium falciparum to the mainstay drugs like chloroquine. New drugs with unique structures and mechanism of action are urgently required to treat sensitive and drug-resistant strains of malaria. Historically, compounds containing novel structure from natural origin represent a major source for the discovery and development of new drugs for several diseases. This review presents recent advances in antimalarial drug discovery from natural sources, including plant extracts, and compounds isolated from plants, bacteria, fungi and marine organisms. These compounds offer new and novel scaffolds for development as antimalarials. The literature from 1998 to October 2008 is reviewed. The review present literature compilation from plant and marine extracts, alkaloids (naphthylisoquinolines, bisbenzylisoquinolines, protoberberines and aporphines, indoles, manzamines, and miscellaneous alkaloids) terpenes (sesquiterpenes, triterpenes, diterpenes, and miscellaneous terpenes) quassinoids, flavonoids, limonoids, chalcones, peptides, xanthones, quinones and coumarines, and miscellaneous antimalarials from nature. The review also provides an outlook to recent semisynthetic approaches to antimalarial drugs discovered from natural sources. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3229 / 3256

页数：28

共 215 条

[1]

Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity [J].