The roles of the new negative T cell costimulatory pathways in regulating autoimmunity

被引：185

作者：

Khoury, SJ

Sayegh, MH

机构：

[1] Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Childrens Hosp, Boston, MA 02115 USA

来源：

IMMUNITY | 2004年 / 20卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(04)00116-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The B7 family of T cell costimulatory molecules has recently acquired several new members. Some of these are activating while others are inhibitory. In this review, we will focus on the novel inhibitory pathways with particular emphasis on the PD-1:PD-L pathway. Understanding the mechanisms of these pathways has implications for development of novel treatment strategies for autoimmune disease, transplantation, tumor immunotherapy, and vaccine development.

引用

收藏

页码：529 / 538

页数：10

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