Neurotrophin-3 mRNA expression in rat intrafusal muscle fibres after denervation and reinnervation

被引：24

作者：

Copray, JCVM

Brouwer, N

机构：

[1] Department of Medical Physiology, University of Groningen, 9712 KZ Groningen

来源：

NEUROSCIENCE LETTERS | 1997年 / 236卷 / 01期

关键词：

neurotrophin-3; mRNA; muscle spindles; neurotrophic factors; proprioception; intrafusal fibres; axotomy;

D O I：

10.1016/S0304-3940(97)00747-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have studied the regulation of the expression of neurotrophin-3 (NT-3) mRNA in neonatal and adult rat muscle spindles after denervation and after denervation followed by reinnervation. Denervation of the intrafusal fibres did not result in an upregulation of the NT-3 mRNA expression but decreased this expression below the detection limit of the in situ hybridization method. Reinnervation of intrafusal fibres restored the NT-3 mRNA expression. The results suggest that the expression of NT-3 mRNA in postnatal muscle spindles is controlled by neuronal factors. The intrafusal fibre derived NT-3 may act as an instructive, feedback messenger for innervating neurons and may play a role in stabilizing and maintaining functional neuromuscular connections. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：41 / 44

页数：4

共 17 条

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