Decrypting the genome's alternative messages

被引：48

作者：

Hartmann, Britta ^{[1
,2
]}

Valcarcel, Juan ^{[1
,2
,3
]}

机构：

[1] Ctr Regulacio Genom, Barcelona 08003, Spain

[2] Univ Pompeu Fabra, Barcelona 08003, Spain

[3] Inst Catalana Recerca & Estudis Avancats, Barcelona 08003, Spain

来源：

CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 03期

关键词：

SPLICING FACTOR SF2/ASF; REGULATORY ELEMENTS; HUMAN TRANSCRIPTOME; MYOTONIC-DYSTROPHY; EXON DEFINITION; GENE-EXPRESSION; GLOBAL ANALYSIS; MOUSE MODEL; RNA; PROTEIN;

D O I：

10.1016/j.ceb.2009.02.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alternative splicing of messenger RNA (mRNA) precursors affects the majority of human genes, has a considerable impact on eukaryotic gene function and offers distinct opportunities for regulation. Alterations in alternative splicing can cause or modify the progression of a significant number of pathologies. Recent high-throughput technologies have uncovered a wealth of transcript diversity generated by alternative splicing, as well as examples for how this diversity can be established and become misregulated. A variety of mechanisms modulate splice site choice coordinately with other cellular processes, from transcription and mRNA editing or decay to miRNA-based regulation and telomerase function. Alternative splicing studies can contribute to our understanding of multiple biological processes, including genetic diversity, speciation, cell/stem cell differentiation, nervous system function, neuromuscular disorders and tumour progression.

引用

页码：377 / 386

页数：10

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