Efficacy of Combined Jejunal and Colonic Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection

被引：81

作者：

Dutta, Sudhir K. ^{[1
,2
]}

Girotra, Mohit ^{[3
]}

Garg, Shashank ^{[4
]}

Dutta, Anand ^{[3
]}

von Rosenvinge, Erik C. ^{[5
,6
]}

Maddox, Cynthia ^{[8
]}

Song, Yang ^{[8
]}

Bartlett, John G. ^{[9
,10
]}

Vinayek, Rakesh ^{[11
]}

Fricke, W. Florian ^{[7
]}

机构：

[1] Univ Maryland, Sch Med, Sinai Hosp Baltimore, Baltimore, MD 21215 USA

[2] Univ Maryland, Dept Gastroenterol, Sinai Hosp Baltimore, Baltimore, MD 21215 USA

[3] Johns Hopkins Univ, Sinai Hosp, Program Internal Med, Div Gastroenterol, Baltimore, MD USA

[4] Johns Hopkins Univ, Sinai Hosp, Program Internal Med, Dept Med, Baltimore, MD USA

[5] Univ Maryland, Sch Med, VA Maryland Hlth Care Syst, Baltimore, MD 21215 USA

[6] Univ Maryland, Dept Gastroenterol, VA Maryland Hlth Care Syst, Baltimore, MD 21215 USA

[7] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[8] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA

[9] Johns Hopkins Univ, Sch Med, Johns Hopkins Hosp, Baltimore, MD USA

[10] Johns Hopkins Univ, Div Infect Dis, Johns Hopkins Hosp, Baltimore, MD USA

[11] Sinai Hosp Baltimore, Dept Hepatol, Baltimore, MD USA

来源：

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2014年 / 12卷 / 09期

关键词：

Fecal Microbiota Transplantation; FMT; Jejunal; Colonic; Clostridium difficile; Recurrent; RCDI; 16s rRNA Analysis; Lachnospiraceae; Microbiota; THERAPY; FECES;

D O I：

10.1016/j.cgh.2013.12.032

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The prevalence of recurrent Clostridium difficile infection (RCDI) is increasing; fecal microbiota transplantation (FMT) is an effective therapy. However, there have been no studies of the efficacy of a single session of combined enteral and colonic FMT or characterizations of changes in the microbiota between donors and recipients. We performed a study of 27 patients with RCDI who were given a fixed volume of processed fecal filtrate via enteroscopy and colonoscopy in a single session. Patients were closely monitored, and fecal samples were collected from 2 patient-donor pairs for 16S rRNA analysis. All patients had reduced stool frequency, abdominal pain, white blood cell counts, and elimination of fecal C difficile toxin (P < .05). FMT increased microbial diversity, increasing proportions of Lachnospiraceae (phylum Firmicutes) and reducing proportions of Enterobacteriaceae. FMT was associated with marked changes in the composition of fecal microbiota in 2 patients with RCDI.

引用

页码：1572 / 1576

页数：5

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