Cathepsins K, L, B, X and W are differentially expressed in normal and chronically inflamed gastric mucosa

被引：45

作者：

Bühling, F

Peitz, U

Krüger, S

Küster, D

Vieth, M

Gebert, I

Roessner, A

Weber, E

Malfertheiner, P

Wex, T

机构：

[1] Univ Magdeburg, Dept Gastroenterol Hepatol & Infect Dis, D-39120 Magdeburg, Germany

[2] Univ Magdeburg, Inst Immunol, D-39120 Magdeburg, Germany

[3] Univ Magdeburg, Inst Pathol, D-39120 Magdeburg, Germany

[4] Univ Halle Wittenberg, Fac Med, Inst Physiol Chem, D-06097 Halle Saale, Germany

来源：

BIOLOGICAL CHEMISTRY | 2004年 / 385卷 / 05期

关键词：

cathepsins; gastric mucosa; gastritis; GERD; H; pylori;

D O I：

10.1515/BC.2004.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of cathepsins K, L, B, X and W was studied by quantitative RTPCR in normal and inflamed gastric mucosa (antrum, corpus, cardia). Cathepsins B, L, K and X were expressed ubiquitously. In contrast, cathepsin W was expressed at very low levels. Infection by Helicobacter pylori caused a significant induction of cathepsin X (p<0.008), whereas the other cathepsins were not or only locally affected by H. pylori infection or reflux disease. Immunohistochemistry revealed specific expression of cathepsin X (macrophages), cathepsin K (parietal cells) and cathepsin W (lymphocytes), whereas cathepsins B and L were predominantly expressed in epithelial cells.

引用

页码：439 / 445

页数：7

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