Four new andrographolide metabolites in human urine

被引：39

作者：

Cui, L

Qiu, F

Wang, NL

Yao, XS ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China

[2] Tradit Chinese Med & Nat Prod Res Ctr Shenzhen, Shenzhen 518057, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 06期

关键词：

andrographolide; metabolites in human urine; sulfate; cysteine S-conjugate;

D O I：

10.1248/cpb.52.772

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Andrographolide one of principal components of a famous traditional Chinese herbal medicine Andro-graphis paniculate (BURM) NEES. Four new metabolites of andrographolide were isolated from human urine. All of them were characterized as sulfate and one of them also as a cysteine S-conjugate. The structures were determined to be andrographolide-3-O-sulfate (M-1), isoandrographolide-3-O-sulfate (M-2), 14-deoxyandrographolide-3-O-sulfate (M-3), 14-deoxy-12-(cysteine-S-yl)-andrographolide-3-O-sulfate (M-4), respectively, based on chemical evidence and spectroscopic analyses.

引用

页码：772 / 775

页数：4

共 16 条

[1]

Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation [J].