Development and Function of Dendritic Cell Subsets

被引：722

作者：

Mildner, Alexander ^{[1
]}

Jung, Steffen ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

IMMUNITY | 2014年 / 40卷 / 05期

关键词：

CD8(+) T-CELLS; STEADY-STATE CONDITIONS; PERIPHERAL LYMPHOID ORGANS; EPIDERMAL LANGERHANS CELLS; TRANSCRIPTION FACTOR E2-2; BLOOD-BORNE ANTIGENS; MOUSE BONE-MARROW; IN-VIVO; CROSS-PRESENTATION; GM-CSF;

D O I：

10.1016/j.immuni.2014.04.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Classical dendritic cells (cDCs) form a critical interface between innate and adaptive immunity. As myeloid immune cell sentinels, cDCs are specialized in the sensing of pathogen challenges and cancer. They translate the latter for T cells into peptide form. Moreover, cDCs provide additional critical information on the original antigen context to trigger a diverse spectrum of appropriate protective responses. Here we review recent progress in our understanding of cDC subsets in mice. We will discuss cDC subset ontogeny and transcription factor dependencies, as well as emerging functional specializations within the cDC compartment in lymphoid and nonlymphoid tissues.

引用

收藏

页码：642 / 656

页数：15

相关论文

共 201 条

[1]

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].

Akashi, K ;

Traver, D ;

Miyamoto, T ;

Weissman, IL .

NATURE, 2000, 404 (6774) :193-197

[2]

Essential role for ICSBP in the in vivo development of murine CD8α+ dendritic cells [J].

Aliberti, J ;

Schulz, O ;

Pennington, DJ ;

Tsujimura, H ;

Sousa, CRE ;

Ozato, K ;

Sher, A .

BLOOD, 2003, 101 (01) :305-310

[3]

Epidermal viral immunity induced by CD8α+ dendritic cells but not by Langerhans cells [J].

Allan, RS ;

Smith, CM ;

Belz, GT ;

van Lint, AL ;

Wakim, LM ;

Heath, WR ;

Carbone, FR .

SCIENCE, 2003, 301 (5641) :1925-1928

[4]

Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells [J].

Anderson, KL ;

Perkin, H ;

Surh, CD ;

Venturini, S ;

Maki, RA ;

Torbett, BE .

JOURNAL OF IMMUNOLOGY, 2000, 164 (04) :1855-1861

[5]

Projection of an immunological self shadow within the thymus by the aire protein [J].

Anderson, MS ;

Venanzi, ES ;

Klein, L ;

Chen, ZB ;

Berzins, SP ;

Turley, SJ ;

von Boehmer, H ;

Bronson, R ;

Dierich, A ;

Benoist, C ;

Mathis, D .

SCIENCE, 2002, 298 (5597) :1395-1401

[6]

THYMIC DENDRITIC CELLS AND T-CELLS DEVELOP SIMULTANEOUSLY IN THE THYMUS FROM A COMMON PRECURSOR POPULATION [J].

ARDAVIN, C ;

WU, L ;

LI, CL ;

SHORTMAN, K .

NATURE, 1993, 362 (6422) :761-763

[7]

Thymic dendritic cells [J].

Ardavin, C .

IMMUNOLOGY TODAY, 1997, 18 (07) :350-361

[8]

A Single Subset of Dendritic Cells Controls the Cytokine Bias of Natural Killer T Cell Responses to Diverse Glycolipid Antigens [J].

Arora, Pooja ;

Baena, Andres ;

Yu, Karl O. A. ;

Saini, Neeraj K. ;

Kharkwal, Shalu S. ;

Goldberg, Michael F. ;

Kunnath-Velayudhan, Shajo ;

Carreno, Leandro J. ;

Venkataswamy, Manjunatha M. ;

Kim, John ;

Lazar-Molnar, Eszter ;

Lauvau, Gregoire ;

Chang, Young-tae ;

Liu, Zheng ;

Bittman, Robert ;

Al-Shamkhani, Aymen ;

Cox, Liam R. ;

Jervis, Peter J. ;

Veerapen, Natacha ;

Besra, Gurdyal S. ;

Porcelli, Steven A. .

IMMUNITY, 2014, 40 (01) :105-116

[9]

Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology [J].

Asselin-Paturel, C ;

Boonstra, A ;

Dalod, M ;

Durand, I ;

Yessaad, N ;

Dezutter-Dambuyant, C ;

Vicari, A ;

O'Garra, A ;

Biron, C ;

Brière, F ;

Trinchieri, G .

NATURE IMMUNOLOGY, 2001, 2 (12) :1144-1150

[10]

Crucial Contribution of Thymic Sirpα+ Conventional Dendritic Cells to Central Tolerance against Blood-Borne Antigens in a CCR2-Dependent Manner [J].

Baba, Tomohisa ;

Nakamoto, Yasunari ;

Mukaida, Naofumi .

JOURNAL OF IMMUNOLOGY, 2009, 183 (05) :3053-3063

← 1 2 3 4 5 6 7 8 9 10 →