Spectral analysis of ventricular fibrillation and closed-chest cardiopulmonary resuscitation

被引:70
作者
Strohmenger, HU [1 ]
Lindner, KH [1 ]
Keller, A [1 ]
Lindner, IM [1 ]
Pfenninger, EG [1 ]
机构
[1] UNIV ULM,ANASTHESIOL KLIN,D-89075 ULM,GERMANY
关键词
cardiac arrest; fast Fourier transformation; microspheres; myocardial blood flow; spectral analysis of ventricular fibrillation;
D O I
10.1016/S0300-9572(96)01003-9
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
This study was designed to assess the interference by closed-chest cardiopulmonary resuscitation (CPR) on the ventricular fibrillation (VF) ECG signal in a porcine model of cardiac arrest and to elucidate which variable of VF spectral analysis reflects best myocardial blood flow and resuscitation success during CPR. Fourteen domestic pigs were allocated to receive either 0.4 U/kg vasopressin (n = 7) or 10 mi saline (n = 7) after 4 min of VF and 3 min of CPR. Using radiolabeled microspheres, myocardial blood flow was determined during CPR before, and 90 s and 5 min after, drug administration. Using spectral analysis of VF, the median frequency, dominant frequency, edge frequency and amplitude of VF were determined simultaneously and before the first defibrillation attempt. Using fillers in order to specify frequency ranges, stepwise elimination of mechanical artifacts resulting from CPR revealed that at a frequency bandpass of 4.3-35 Hz, median fibrillation frequency has a sensitivity, specificity, positive and negative predictive value of 100% to differentiate between resuscitated and non-resuscitated animals. The best correlation between myocardial blood flow and fibrillation frequency was found at a median frequency range of 4.3-35 Hz. We conclude that spectral analysis of VF can provide reliable information relating to successful resuscitation. In this model after elimination of oscillations due to mechanical CPR, median fibrillation frequency best reflects the probability of resuscitation success. Copyright (C) 1996 Elsevier Science Ireland Ltd
引用
收藏
页码:155 / 161
页数:7
相关论文
共 15 条
  • [1] ESTIMATING THE DURATION OF VENTRICULAR-FIBRILLATION
    BROWN, CG
    DZWONCZYK, R
    WERMAN, HA
    HAMLIN, RL
    [J]. ANNALS OF EMERGENCY MEDICINE, 1989, 18 (11) : 1181 - 1185
  • [2] MEDIAN FREQUENCY - A NEW PARAMETER FOR PREDICTING DEFIBRILLATION SUCCESS RATE
    BROWN, CG
    GRIFFITH, RF
    VANLIGTEN, P
    HOEKSTRA, J
    NEJMAN, G
    MITCHELL, L
    DZWONCZYK, R
    [J]. ANNALS OF EMERGENCY MEDICINE, 1991, 20 (07) : 787 - 789
  • [3] FOURIER-ANALYSIS OF VENTRICULAR-FIBRILLATION OF VARIED ETIOLOGY
    CARLISLE, EJF
    ALLEN, JD
    KERNOHAN, WG
    ANDERSON, J
    ADGEY, AAJ
    [J]. EUROPEAN HEART JOURNAL, 1990, 11 (02) : 173 - 181
  • [4] VENTRICULAR-FIBRILLATION MASQUERADING AS VENTRICULAR STANDSTILL
    EWY, GA
    DAHL, CF
    ZIMMERMAN, M
    OTTO, C
    [J]. CRITICAL CARE MEDICINE, 1981, 9 (05) : 392 - 392
  • [5] BLOOD-FLOW MEASUREMENTS WITH RADIONUCLIDE-LABELED PARTICLES
    HEYMANN, MA
    PAYNE, BD
    HOFFMAN, JIE
    RUDOLPH, AM
    [J]. PROGRESS IN CARDIOVASCULAR DISEASES, 1977, 20 (01) : 55 - 79
  • [6] Kjekshus J, 1990, AM J CARDIOL, V65, p42I
  • [7] INTEGRATION OF ABSOLUTE VENTRICULAR-FIBRILLATION VOLTAGE CORRELATES WITH SUCCESSFUL DEFIBRILLATION
    KUELZ, KW
    HSIA, PW
    WISE, RM
    MAHMUD, R
    DAMIANO, RJ
    [J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1994, 41 (08) : 782 - 791
  • [8] VASOPRESSIN IMPROVES VITAL ORGAN BLOOD-FLOW DURING CLOSED-CHEST CARDIOPULMONARY-RESUSCITATION IN PIGS
    LINDNER, KH
    PRENGEL, AW
    PFENNINGER, EG
    LINDNER, IM
    STROHMENGER, HU
    GEORGIEFF, M
    LURIE, KG
    [J]. CIRCULATION, 1995, 91 (01) : 215 - 221
  • [9] FREQUENCY-ANALYSIS OF THE HUMAN AND SWINE ELECTROCARDIOGRAM DURING VENTRICULAR-FIBRILLATION
    MARTIN, DR
    BROWN, CG
    DZWONCZYK, R
    [J]. RESUSCITATION, 1991, 22 (01) : 85 - 91
  • [10] RELATION BETWEEN POWER SPECTRUM TIME COURSE DURING VENTRICULAR-FIBRILLATION AND ELECTROMECHANICAL DISSOCIATION - EFFECTS OF CORONARY PERFUSION AND NIFEDIPINE
    MARTIN, G
    COSIN, J
    SUCH, M
    HERNANDEZ, A
    LLAMAS, P
    [J]. EUROPEAN HEART JOURNAL, 1986, 7 (07) : 560 - 569