Cytoskeletal regulation: Rich in lipids

被引:176
作者
Janmey, PA
Lindberg, U
机构
[1] Univ Penn, IME, Philadelphia, PA 19104 USA
[2] Stockholm Univ, Dept Zool Cell Biol, Wenner Gren Inst, S-10691 Stockholm, Sweden
关键词
D O I
10.1038/nrm1434
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Phosphorylated derivatives of the phospholipid phosphatidylinositol, or phosphoinositides, are implicated in many aspects of cell function. Binding of phosphoinositides that are localized within cell membranes to soluble protein ligands allows spatially selective regulation at the cytoplasm-membrane interface. Recently, studies that relate phosphoinositide production to membrane domains are converging with those that show effects of these lipids on the assembly of cellular actin, and are therefore linking membrane and cytoskeletal structures in new ways.
引用
收藏
页码:658 / 666
页数:9
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