Cytoskeletal regulation: Rich in lipids

被引：176

作者：

Janmey, PA

Lindberg, U

机构：

[1] Univ Penn, IME, Philadelphia, PA 19104 USA

[2] Stockholm Univ, Dept Zool Cell Biol, Wenner Gren Inst, S-10691 Stockholm, Sweden

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 08期

关键词：

D O I：

10.1038/nrm1434

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphorylated derivatives of the phospholipid phosphatidylinositol, or phosphoinositides, are implicated in many aspects of cell function. Binding of phosphoinositides that are localized within cell membranes to soluble protein ligands allows spatially selective regulation at the cytoplasm-membrane interface. Recently, studies that relate phosphoinositide production to membrane domains are converging with those that show effects of these lipids on the assembly of cellular actin, and are therefore linking membrane and cytoskeletal structures in new ways.

引用

收藏

页码：658 / 666

页数：9

相关论文

共 101 条

[11] The crystal structure of plasma gelsolin: Implications for actin severing, capping, and nucleation [J].

Burtnick, LD ;

Koepf, EK ;

Grimes, J ;

Jones, EY ;

Stuart, DI ;

McLaughlin, PJ ;

Robinson, RC .

CELL, 1997, 90 (04) :661-670

[12] Shape instabilities in charged lipid domains [J].

Cebers, A ;

Janmey, PA .

JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (47) :12351-12353

[13]

Cockcroft S., 2000, BIOL PHOSPHOINOSITID

[14] Inhibition of phosphatidylinositol-4-phosphate 5-kinase Iα impairs localized actin remodeling and suppresses phagocytosis [J].

Coppolino, MG ;

Dierckman, R ;

Loijens, J ;

Collins, RF ;

Pouladi, M ;

Jongstra-Bilen, J ;

Schreiber, AD ;

Trimble, WS ;

Anderson, R ;

Grinstein, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (46) :43849-43857

[15] A new phosphatidylinositol 4,5-bisphosphate-binding site located in the C2 domain of protein kinase Cα [J].

Corbalán-García, S ;

García-García, J ;

Rodríguez-Alfaro, JA ;

Gómez-Fernández, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (07) :4972-4980

[16] Phosphoinositides differentially regulate α-actinin flexibility and function [J].

Corgan, AM ;

Singleton, C ;

Santoso, CB ;

Greenwood, JA .

BIOCHEMICAL JOURNAL, 2004, 378 :1067-1072

[17] Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly [J].

Cunningham, CC ;

Vegner, R ;

Bucki, R ;

Funaki, M ;

Korde, N ;

Hartwig, JH ;

Stossel, TP ;

Janmey, PA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (46) :43390-43399

[18] Eukaryotic chemotaxis: Distinctions between directional sensing and polarization [J].

Devreotes, P ;

Janetopoulos, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (23) :20445-20448

[19] Phosphatidylinositol phosphate kinases put PI4,5P2 in its place [J].

Doughman, RL ;

Firestone, AJ ;

Anderson, RA .

JOURNAL OF MEMBRANE BIOLOGY, 2003, 194 (02) :77-89

[20] Membrane ruffling requires coordination between type Iα phosphatidylinositol phosphate kinase and Rac signaling [J].

Doughman, RL ;

Firestone, AJ ;

Wojtasiak, ML ;

Bunce, MW ;

Anderson, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (25) :23036-23045

← 1 2 3 4 5 6 7 8 9 10 →