Strategies for the prevention of antimalarial drug resistance: Rationale for combination chemotherapy for malaria

Among the several 'tropical' diseases that affect humans, malaria poses special control problems due to the increasing population at risk from the disease, the difficulties in eradicating the mosquito vector in the tropics and the emergence and spread of parasite resistance to commonly used antimalarial drugs. There is both clinical experience and experimental evidence that, however effective when first introduced, the lifespan of drugs is inevitably curtailed by the emergence of resistant parasites. Resistance is the most important factor in determining the useful lifespan of antimalarial drugs. In this' review, Nick White and Piero Olliaro discuss the rationale for combination chemotherapy.