Synthesis and characterization of thermo- and pH-sensitive block copolymers bearing a biotin group at the poly(ethylene oxide) chain end

被引：14

作者：

Tong, Dajun ^{[1
]}

Yao, Jia ^{[1
]}

Li, Haoran ^{[1
]}

Han, Shijun ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2006年 / 102卷 / 04期

关键词：

H2N-PEO-PDMAEMA; anionic polymerization; block copolymer; biotin; site-specific drug delivery;

D O I：

10.1002/app.24812

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A poly(ethylene oxide)-block-poly(dimethylamino ethyl methacrylate) block copolymer (PEO-b-PDMAEMA) bearing an amino moiety at the PEO chain end was synthesized by a one-pot sequential oxyanionic polymerization of ethylene oxide (EO) and dimethylamino ethyl methacrylate (DMAEMA), followed by a coupling reaction between its PEO amino and a biotin derivative. The polymers were characterized with H-1 NMR spectroscopy and gel permeation chromatography. Activated biotin, biotin-NHS (N-hydroxysucci-nimide), was used to synthesize biotin-PEO-PDMAEMA. In aqueous media, the solubility of the copolymer was temperature- and pH-sensitive. The particle size of the micelle formed from functionalized block copolymers was determined by dynamic light scattering. (c) 2006 Wiley Periodicals, Inc.

引用

页码：3552 / 3558

页数：7

共 38 条

[1] Amphiphilic block copolymers for drug delivery [J].

Adams, ML ;

Lavasanifar, A ;

Kwon, GS .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 92 (07) :1343-1355

[2] Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26 [J].

Aktas, Y ;

Yemisci, M ;

Andrieux, K ;

Gürsoy, RN ;

Alonso, MJ ;

Fernandez-Megia, E ;

Novoa-Carballal, R ;

Quiñoá, E ;

Riguera, R ;

Sargon, MF ;

Çelik, HH ;

Demir, AS ;

Hincal, AA ;

Dalkara, T ;

Çapan, Y ;

Couvreur, P .

BIOCONJUGATE CHEMISTRY, 2005, 16 (06) :1503-1511

[3] Drug delivery systems: Entering the mainstream [J].

Allen, TM ;

Cullis, PR .

SCIENCE, 2004, 303 (5665) :1818-1822

[4] Biophysical characterization of complexation of DNA with block copolymers of poly(2-dimethylaminoethyl) methacrylate, poly(ethylene oxide), and poly(propylene oxide) [J].

Alvarez-Lorenzo, C ;

Barreiro-Iglesias, R ;

Concheiro, A ;

Iourtchenko, L ;

Alakhov, V ;

Bromberg, L ;

Temchenko, M ;

Deshmukh, S ;

Hatton, TA .

LANGMUIR, 2005, 21 (11) :5142-5148

[5] Synthesis and characterization of injectable, water-soluble copolymers of tertiary amine methacrylates and poly(ethylene glycol) containing methacrylates [J].

Anderson, BC ;

Mallapragada, SK .

BIOMATERIALS, 2002, 23 (22) :4345-4352

[6] Covalent functionalization for biomolecular recognition on vertically aligned carbon nanofibers [J].

Baker, SE ;

Tse, KY ;

Hindin, E ;

Nichols, BM ;

Clare, TL ;

Hamers, RJ .

CHEMISTRY OF MATERIALS, 2005, 17 (20) :4971-4978

[7] Polycationic block copolymers of poly(ethylene oxide) and poly(propylene oxide) for cell transfection [J].

Bromberg, L ;

Deshmukh, S ;

Temchenko, M ;

Iourtchenko, L ;

Alakhov, V ;

Alvarez-Lorenzo, C ;

Barreiro-Iglesias, R ;

Concheiro, A ;

Hatton, TA .

BIOCONJUGATE CHEMISTRY, 2005, 16 (03) :626-633

[8] Effect of polyethylene oxide blocks or grafts on the physicochemical properties of poly(2-N-(dimethylaminoethyl) methacrylate) DNA complexes [J].

Dubruel, P ;

Schacht, EH .

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 2000, 15 (04) :279-296

[9] Controlled/living polymerization of 2-(diethylamino) ethyl methacrylate and its block copolymer with tert-butyl methacrylate by atom transfer radical polymerization [J].

Gan, LH ;

Ravi, P ;

Mao, BW ;

Tam, KC .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2003, 41 (17) :2688-2695

[10] Effective drug delivery by PEGylated drug conjugates [J].

Greenwald, RB ;

Choe, YH ;

McGuire, J ;

Conover, CD .

ADVANCED DRUG DELIVERY REVIEWS, 2003, 55 (02) :217-250

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