PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine

被引:803
作者
Lin, Chien-Chi [1 ,2 ]
Anseth, Kristi S. [1 ,2 ]
机构
[1] Univ Colorado, Dept Chem & Biol Engn, Boulder, CO 80309 USA
[2] Howard Hughes Med Inst, Chevy Chase, MD USA
关键词
controlled release; hydrogel; PEG; regenerative medicine; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR DELIVERY; THIOL-ACRYLATE PHOTOPOLYMERIZATIONS; CHONDROGENIC DIFFERENTIATION; PROTEIN DELIVERY; IN-VIVO; OSTEOGENIC DIFFERENTIATION; COMPLEXATION HYDROGELS; CONJUGATE ADDITION; CLICK CHEMISTRY;
D O I
10.1007/s11095-008-9801-2
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Polyethylene glycol (PEG) hydrogels are widely used in a variety of biomedical applications, including matrices for controlled release of biomolecules and scaffolds for regenerative medicine. The design, fabrication, and characterization of PEG hydrogels rely on the understanding of fundamental gelation kinetics as well as the purpose of the application. This review article will focus on different polymerization mechanisms of PEG-based hydrogels and the importance of these biocompatible hydrogels in regenerative medicine applications. Furthermore, the design criteria that are important in maintaining the availability and stability of the biomolecules as well as the mechanisms for loading of biomolecules within PEG hydrogels will also be discussed. Finally, we overview and provide a perspective on some of the emerging novel design and applications of PEG hydrogel systems, including the spatiotemporal-controlled delivery of biomolecules, hybrid hydrogels, and PEG hydrogels designed for controlled stem cell differentiation.
引用
收藏
页码:631 / 643
页数:13
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