Chromatin assembly - Cooperation between histone chaperones and ATP-dependent nucleosome remodeling machines
被引:112
作者:
Tyler, JK
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Sch Med B121, Dept Biochem & Mol Genet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Sch Med B121, Dept Biochem & Mol Genet, Denver, CO 80262 USA
Tyler, JK
[1
]
机构:
[1] Univ Colorado, Hlth Sci Ctr, Sch Med B121, Dept Biochem & Mol Genet, Denver, CO 80262 USA
来源:
EUROPEAN JOURNAL OF BIOCHEMISTRY
|
2002年
/
269卷
/
09期
关键词:
chromatin;
histone chaperone;
nucleosome remodeling;
acetylation;
DNA replication;
DNA repair;
CAF-1;
ACF;
ASF1;
Rad53;
D O I:
10.1046/j.1432-1033.2002.02890.x
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Chromatin is a highly dynamic structure that plays an essential role in regulating all nuclear processes that utilize the DNA template including DNA repair, replication, transcription and recombination. Thus, the mechanisms by which chromatin structures are assembled and modified are questions of broad interest. This minireview will focus on two groups of proteins: (a) histone chaperones and (b) ATP-dependent chromatin remodeling machines, that co-operate to assemble DNA and histone proteins into chromatin. The current understanding of how histone chaperones and ATP-dependent remodeling machines coordinately assemble chromatin in vitro will be discussed, together with the growing body of genetic evidence that supports the role of histone chaperones in the cell.