Functional magnetic resonance imaging and cognition at the very early stage of MS

被引:41
作者
Audoin, Bertrand
Duong, My Van Au
Malikova, Irina
Confort-Gouny, Sylviane
Ibarrola, Danielle
Cozzone, Patrick J.
Pelletier, Jean
Ranjeva, Jean-Philippe
机构
[1] Fac Med, Ctr Resonance Magnet Biol & Med, CRMBM CNRS 6612, F-13005 Marseille, France
[2] Timone Hosp, Dept Neurol, Marseille, France
关键词
cognitive impairment; clinically isolated syndrome; effective connectivity; fMRI; functional connectivity; compensatory mechanisms; multiple sclerosis; working memory;
D O I
10.1016/j.jns.2005.08.026
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Dysfunction of high controlled information processing is present in patients with multiple sclerosis (MS) right at the beginning of the disease. One hypothesis is that disruption of communication inside large-scale cortical networks, occurring as a consequence of white matter damage, may constitute the anatomical substrate of cognitive impairment at the very early stage of MS. Disturbance of interregional synchronization might be the main pathogenic factor in controlled information processing deficiency in early MS. Preliminary functional MRI studies (fMRI) have provided important clues to corroborate the connectivity hypotheses. First, brain connectivity assessed by fMRI has brought new data about the influence of diffuse white matter damage on connectivity efficiency inside large-scale networks. These studies have suggested that connectivity disturbances occur inside the working memory network in patients at the very early stage of MS and appear related to the extent of structural white matter damage. Also, fMRI studies have suggested that patients may partially compensate for connectivity impairment by a greater cognitive control. Such a compensatory mechanism could limit the determinant functional impact of diffuse white matter damage on high controlled information processing. (c) 2006 Elsevier B.V All rights reserved.
引用
收藏
页码:87 / 91
页数:5
相关论文
共 44 条
[11]   Editorial [J].
Cartei, G .
ANNALS OF ONCOLOGY, 1999, 10 :1-1
[12]   Anterior cingulate cortex, error detection, and the online monitoring of performance [J].
Carter, CS ;
Braver, TS ;
Barch, DM ;
Botvinick, MM ;
Noll, D ;
Cohen, JD .
SCIENCE, 1998, 280 (5364) :747-749
[13]   Temporal dynamics of brain activation during a working memory task [J].
Cohen, JD ;
Perlstein, WM ;
Braver, TS ;
Nystrom, LE ;
Noll, DC ;
Jonides, J ;
Smith, EE .
NATURE, 1997, 386 (6625) :604-608
[14]   A neuronal model of a global workspace in effortful cognitive tasks [J].
Dehaene, S ;
Kerszberg, M ;
Changeux, JP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (24) :14529-14534
[15]   A neuronal network model linking subjective reports and objective physiological data during conscious perception [J].
Dehaene, S ;
Sergent, C ;
Changeux, JP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (14) :8520-8525
[16]   Altered functional connectivity related to white matter changes inside the working memory network at the very early stage of MS [J].
Duong, MVA ;
Audoin, B ;
Boulanouar, K ;
Ibarrola, D ;
Malikova, I ;
Confort-Gouny, S ;
Celsis, P ;
Pelletier, J ;
Cozzone, PJ ;
Ranjeva, JP .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2005, 25 (10) :1245-1253
[17]   Modulation of effective connectivity inside the working memory network in patients at the earliest stage of multiple sclerosis [J].
Duong, MVA ;
Boulanouar, K ;
Audoin, B ;
Treseras, S ;
Ibarrola, D ;
Malikova, I ;
Confort-Gouny, S ;
Celsis, P ;
Pelletier, J ;
Cozzone, PJ ;
Ranjeva, JP .
NEUROIMAGE, 2005, 24 (02) :533-538
[18]   Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis [J].
Fernando, KTM ;
McLean, MA ;
Chard, DT ;
MacManus, DG ;
Dalton, CM ;
Miszkiel, KA ;
Gordon, RM ;
Plant, GT ;
Thompson, AJ ;
Miller, DH .
BRAIN, 2004, 127 :1361-1369
[19]   Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis [J].
Filippi, M ;
Bozzali, M ;
Rovaris, M ;
Gonen, O ;
Kesavadas, C ;
Ghezzi, A ;
Martinelli, V ;
Grossman, RI ;
Scotti, G ;
Comi, G ;
Falini, A .
BRAIN, 2003, 126 :433-437
[20]   FUNCTIONAL CONNECTIVITY - THE PRINCIPAL-COMPONENT ANALYSIS OF LARGE (PET) DATA SETS [J].
FRISTON, KJ ;
FRITH, CD ;
LIDDLE, PF ;
FRACKOWIAK, RSJ .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1993, 13 (01) :5-14