Novel Imaging Provides New Insights into Mechanisms of Oxygen Transport in Tumors

被引：44

作者：

Hardee, Matthew E. ^{[2
]}

Dewhirst, Mark W. ^{[1
]}

Agarwal, Nikita ^{[3
]}

Sorg, Brian S. ^{[3
]}

机构：

[1] Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Internal Med, New York, NY 10021 USA

[3] Univ Florida, Dept Biomed Engn, Gainesville, FL USA

来源：

CURRENT MOLECULAR MEDICINE | 2009年 / 9卷 / 04期

关键词：

DOUBLE-BLIND; BLOOD-FLOW; INTERMITTENT HYPOXIA; DARBEPOETIN-ALPHA; HEMOGLOBIN LEVELS; ANEMIC PATIENTS; PHASE-III; CANCER; ERYTHROPOIETIN; ANGIOGENESIS;

D O I：

10.2174/156652409788167122

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Hypoxia is a common feature of solid tumors, and abnormal tumor oxygen transport is a key factor in the imbalance between tumor oxygen supply and demand. Novel advanced imaging techniques can enable new insights into the complexities of tumor oxygen transport and hypoxia that were not previously known or fully appreciated. In this paper, we document new insights into tumor oxygen transport enabled by spectral imaging of microvascular hemoglobin saturation.

引用

页码：435 / 441

页数：7

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