Shaping of an effective immune microenvironment to and by cancer cells

被引：34

作者：

Becht, Etienne ^{[1
,2
,3
]}

Goc, Jeremy ^{[1
,2
,3
]}

Germain, Claire ^{[1
,2
,3
]}

Giraldo, Nicolas A. ^{[1
,2
,3
]}

Dieu-Nosjean, Marie-Caroline ^{[1
,2
,3
]}

Sautes-Fridman, Catherine ^{[1
,2
,3
]}

Fridman, Wolf-Herman ^{[1
,2
,3
]}

机构：

[1] Cordeliers Res Ctr, Lab Canc Immune Control & Escape, INSERM, UMRS 1138, F-75270 Paris 06, France

[2] Univ Paris 05, Paris, France

[3] Univ Paris 06, Paris, France

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2014年 / 63卷 / 10期

关键词：

Tertiary lymphoid structures (TLS); Tumor shaping of immune contextures; Prognostic impact of immune cells; Immune microenvironment; TERTIARY LYMPHOID STRUCTURES; LUNG-CANCER; T-CELLS; INFILTRATING LYMPHOCYTES; BREAST-CANCER; HUMAN TUMORS; SURVIVAL; CONTEXTURE; CARCINOMA; MELANOMA;

D O I：

10.1007/s00262-014-1590-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

A high density of intratumoral effector memory CD8+/Th1 T cells is associated with favorable prognosis in most cancers and may be induced or increased by immunotherapy. Efficient adaptive immune reactions are shaped in tumor adjacent tertiary lymphoid structures, which exhibit all characteristics of immunity generating lymphoid formations in reactive lymph nodes. Malignant tumor cells impact favorably or deleteriously their immune microenvironment if they bear genetic mutations that result in neo-antigens or by producing chemokines and cytokines that recruit lymphocytes and myeloid cells or increase inflammation and neo-angiogenesis. This intricate network of interactions results in control or escape of tumors, and its understanding will help define goals to monitor efficiency of immunotherapies.

引用

页码：991 / 997

页数：7

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