A combinatorial approach for development of materials for optical sensing of gases

被引:41
作者
Apostolidis, A
Klimant, I
Andrzejewski, D
Wolfbeis, OS [1 ]
机构
[1] Univ Regensburg, Inst Analyt Chem, D-93040 Regensburg, Germany
[2] Graz Univ Technol, Inst Analyt Chem, A-8010 Graz, Austria
来源
JOURNAL OF COMBINATORIAL CHEMISTRY | 2004年 / 6卷 / 03期
关键词
D O I
10.1021/cc034040l
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
We present a combinatorial approach for development of materials for use in optical gas sensors, with oxygen being used as an exemplary target gas. Combinatorial chemistry is shown to be a promising tool for speeding up the search for new sensor materials. The method is based on the use of various polymers, solvents, indicators, plasticizers, and other additives. Solutions of the respective materials are prepared in appropriate organic solvents, and a robotic station is programmed to mix the components. Spots of the sensing materials are deposited in the wells of glass substrates resembling microtiterplates. After drying off the solvent, the sensor Spots are automatically analyzed in a test stand, where they are exposed to a carrier gas containing oxygen in various concentrations. Changes in the decay time of fluorescence of the indicator probes are measured and used (along with sensor response time) as a main criterion for sensor assessment. It is shown that the combinatorial approach can reduce the time and effort needed to establish libraries of sensor materials by a factor of at least 1000. We describe in detail the device for preparation of sensor libraries and for testing the respective materials. The potential of the system is demonstrated for the characterization of optical oxygen sensors.
引用
收藏
页码:325 / 331
页数:7
相关论文
共 25 条
[1]   Probes and polymers for optical sensing of oxygen [J].
Amao, Y .
MICROCHIMICA ACTA, 2003, 143 (01) :1-12
[2]   High-throughput synthesis of nanoscale materials:: Structural optimization of functionalized one-step star polymers [J].
Bosman, AW ;
Heumann, A ;
Klaerner, G ;
Benoit, D ;
Fréchet, JMJ ;
Hawker, CJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (26) :6461-6462
[3]   Generating sensor diversity through combinatorial polymer synthesis [J].
Dickinson, TA ;
Walt, DR ;
White, J ;
Kauer, JS .
ANALYTICAL CHEMISTRY, 1997, 69 (17) :3413-3418
[4]   EFFECTS OF POLYMER MATRICES ON THE TIME-RESOLVED LUMINESCENCE OF A RUTHENIUM COMPLEX QUENCHED BY OXYGEN [J].
DRAXLER, S ;
LIPPITSCH, ME ;
KLIMANT, I ;
KRAUS, H ;
WOLFBEIS, OS .
JOURNAL OF PHYSICAL CHEMISTRY, 1995, 99 (10) :3162-3167
[5]   OPTICAL FLUORESCENCE AND ITS APPLICATION TO AN INTRAVASCULAR BLOOD-GAS MONITORING-SYSTEM [J].
GEHRICH, JL ;
LUBBERS, DW ;
OPITZ, N ;
HANSMANN, DR ;
MILLER, WW ;
TUSA, JK ;
YAFUSO, M .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1986, 33 (02) :117-132
[6]   Applications of combinatorial methods in catalysis [J].
Hagemeyer, A ;
Jandeleit, B ;
Liu, YM ;
Poojary, DM ;
Turner, HW ;
Volpe, AF ;
Weinberg, WH .
APPLIED CATALYSIS A-GENERAL, 2001, 221 (1-2) :23-43
[7]   OPTICAL SENSORS FOR IN-VITRO BLOOD-GAS ANALYSIS [J].
LEINER, MJP .
SENSORS AND ACTUATORS B-CHEMICAL, 1995, 29 (1-3) :169-173
[8]  
LEIPERT D, 1999, COMBINATORIAL CHEM, pCH10
[9]   FIBRE-OPTIC OXYGEN SENSOR WITH THE FLUORESCENCE DECAY TIME AS THE INFORMATION CARRIER [J].
LIPPITSCH, ME ;
PUSTERHOFER, J ;
LEINER, MJP ;
WOLFBEIS, OS .
ANALYTICA CHIMICA ACTA, 1988, 205 (1-2) :1-6
[10]  
MILLER WW, 1987, CLIN CHEM, V33, P1538