Histone methylation: Dynamic or static?

被引：399

作者：

Bannister, AJ ^{[1
]}

Schneider, R ^{[1
]}

Kouzarides, T ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Wellcome Trust Canc Res UK Inst, Cambridge CB2 1QR, England

来源：

CELL | 2002年 / 109卷 / 07期

关键词：

D O I：

10.1016/S0092-8674(02)00798-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Methylation of histones mediates transcriptional silencing at heterochromatin sites and affects regulated transcription at euchromatic loci. So is the methyl group a permanent mark on histones, or can it be removed by an active process necessary for regulated gene expression?

引用

页码：801 / 806

页数：6

共 32 条

[11] Deimination of arginine residues in nucleophosmin/B23 and histones in HL-60 granulocytes
Hagiwara, T
Nakashima, K
Hirano, H
Senshu, T
Yamada, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 290 (03) : 979 - 983
[12] Characterization of the FAD-containing N-methyltryptophan oxidase from Escherichia coli
Khanna, P
Jorns, MS
[J]. BIOCHEMISTRY, 2001, 40 (05) : 1441 - 1450
[13] KIM S, 1964, J BIOL CHEM, V239, P3790
[14] Histone methylation in transcriptional control
Kouzarides, T
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (02) : 198 - 209
[15] Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M
O'Carroll, N
Rea, S
Mechtler, K
Jenuwein, T
[J]. NATURE, 2001, 410 (6824) : 116 - 120
[16] Crystal structure of the nucleosome core particle at 2.8 angstrom resolution
Luger, K
Mader, AW
Richmond, RK
Sargent, DF
Richmond, TJ
[J]. NATURE, 1997, 389 (6648) : 251 - 260
[17] Rb targets histone H3 methylation and HP1 to promoters
Nielsen, SJ
Schneider, R
Bauer, UM
Bannister, AJ
Morrison, A
O'Carroll, D
Firestein, R
Cleary, M
Jenuwein, T
Herrera, RE
Kouzarides, T
[J]. NATURE, 2001, 412 (6846) : 561 - 565
[18] OGAWA T, 1989, J BIOL CHEM, V264, P10205
[19] EPSILON-ALKYLLYSINASE NEW ASSAY METHOD, PURIFICATION, AND BIOLOGICAL SIGNIFICANCE
PAIK, WK
KIM, S
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1974, 165 (01) : 369 - 378
[20] ENZYMATIC DEMETHYLATION OF CALF THYMUS HISTONES
PAIK, WK
KIM, S
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1973, 51 (03) : 781 - 788

← 1 2 3 4 →