The role of biomaterials in stem cell differentiation: Applications in the musculoskeletal system

被引：73

作者：

Elisseeff, J. ^{[1
]}

Ferran, A. ^{[1
]}

Hwang, S. ^{[1
]}

Varghese, S. ^{[1
]}

Zhang, Z. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA

来源：

STEM CELLS AND DEVELOPMENT | 2006年 / 15卷 / 03期

关键词：

D O I：

10.1089/scd.2006.15.295

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The capabilities of stem cells continue to be revealed, leading to excitement regarding potential new therapies. Regenerative medicine is an area in which stem cells hold great promise for overcoming the challenge of limited cell sources for tissue repair. Biomaterials play an important role in directing tissue growth and may provide another tool to manipulate and control stem cell behavior. Biomaterials are made from natural or synthetic polymers and can be processed into three-dimensional scaffolds designed to promote cell proliferation and/or differentiation that ultimately produces new tissue. Stem cells will have a significant impact on the fields of regenerative medicine and tissue engineering as a powerful cell source that will work, in conjunction with biomaterials, to treat tissue and organ loss. Herein, we survey our latest research on applying embryonic stem (ES) cells to hydrogel biomaterials for engineering musculoskeletal tissues, emphasizing the unique biomaterial requirements of ES cells for differentiation and tissue development.

引用

页码：295 / 303

页数：9

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