Labeling and biodistribution studies of Tc-99m radiopharmaceuticals with (o-hydroxyphenyl)diphenylphosphine

被引：7

作者：

Bolzati, C

Uccelli, L

Refosco, F

Tisato, F

Duatti, A

Giganti, M

Piffanelli, A

机构：

[1] UNIV FERRARA,DEPT CLIN & EXPT MED,NUCL MED LAB,I-44100 FERRARA,ITALY

[2] CNR,ICTIMA,PADUA,ITALY

[3] UNIV BOLOGNA,DEPT PHYS & INORGAN CHEM,BOLOGNA,ITALY

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1998年 / 25卷 / 01期

关键词：

technetium-99m; radiopharmaceuticals; heterophosphines; oxo and nitrido complexes;

D O I：

10.1016/S0969-8051(97)00150-9

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

New Tc-99m radiopharmaceuticals with the ligand (o-hydroxyphenyl)diphenylphosphine have been prepared and their biodistributions evaluated in rats. The monoxo Tc(V) complex [Tc-99m(O)Cl(PO)(2)], the Tc(IV) complex [Tc-99m(OH)(2)(PO)(2)], the Tc(III) complex [Tc-99m(PO)(3)], and the nitrido Tc(V) complex [Tc-99m(N)(PO)(2)] have been characterized by TLC and HPLC chromatography, and their chemical structure elucidated by comparison with the corresponding complexes obtained using the P-emitting isotope Tc-99g. Biodistribution studies of these complexes have been carried out in rats. (C) 1998 Elsevier Science Inc.

引用

页码：71 / 76

页数：6

共 16 条

[1] STUDIES OF TECHNETIUM COMPLEXES .9. USE OF THE TETRACHLORONITRIDOTECHNETATE(VI) ANION FOR THE PREPARATION OF NITRIDO COMPLEXES OF TECHNETIUM - CRYSTAL-STRUCTURE OF BIS(8-QUINOLINETHIOLATO)NITRIDOTECHNETIUM(V) [J].