Diffuse infiltrative lung disease associated with flecainide - Report of two cases

被引：16

作者：

Pesenti, S

Lauque, D

Daste, G

Boulay, V

Pujazon, MC

Carles, P

机构：

[1] Hop Purpan, Serv Med Interne, F-31059 Toulouse, France

[2] Hop Purpan, Lab Anatomopathol, F-31059 Toulouse, France

来源：

RESPIRATION | 2002年 / 69卷 / 02期

关键词：

pneumonitis; flecainide;

D O I：

10.1159/000056325

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

We present two patients who developed subacute diffuse infiltrative lung disease while receiving flecainide for supraventricular arrhythmia. They had bilateral subpleural lung opacities on computed tomography. Bronchoalveolar lavage revealed increased numbers of lymphocytes and eosinophils, and a low CD4/CD8 ratio. Nonspecific interstitial pneumonia was documented by open lung biopsy in patient 1. The outcome was favorable after flecainide withdrawal and prednisone treatment. Drug-induced pneumonitis should be suspected in patients treated with flecainide presenting with subacute diffuse infiltrative lung disease. Copyright (C) 2002 S, Karger AG, Basel.

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收藏

页码：182 / 185

页数：4

相关论文

共 13 条

[1] FLECAINIDE-ASSOCIATED PNEUMONITIS [J].

AKOUN, GM ;

CADRANEL, JL ;

ISRAELBIET, D ;

GAUTHIERRAHMAN, S .

LANCET, 1991, 337 (8732) :49-49

[2] ORAL FLECAINIDE ACETATE FOR THE TREATMENT OF VENTRICULAR ARRHYTHMIAS [J].

ANDERSON, JL ;

STEWART, JR ;

PERRY, BA ;

VANHAMERSVELD, DD ;

JOHNSON, TA ;

CONARD, GJ ;

CHANG, SF ;

KVAM, DC ;

PITT, B .

NEW ENGLAND JOURNAL OF MEDICINE, 1981, 305 (09) :473-477

[3] Nonspecific interstitial pneumonia - Individualization of a clinicopathologic entity in a series of 12 patients [J].

Cottin, V ;

Donsbeck, AV ;

Revel, D ;

Loire, R ;

Cordier, JF .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 158 (04) :1286-1293

[4] PULMONARY FIBROSIS ASSOCIATED WITH TOCAINIDE - REPORT OF A CASE WITH LITERATURE-REVIEW [J].

FEINBERG, L ;

TRAVIS, WD ;

FERRANS, V ;

SATO, N ;

BERNTON, HF .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (02) :505-508

[5] Drugs that may injure the respiratory system [J].

Foucher, P ;

Biour, M ;

Blayac, JP ;

Godard, P ;

Sgro, C ;

Kuhn, M ;

Vergnon, JM ;

Vervloet, D ;

Pfitzenmeyer, P ;

Ollagnier, M ;

Mayaud, C ;

Camus, P .

EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (02) :265-279

[6] EXTRACARDIAC ADVERSE-EFFECTS OF FLECAINIDE [J].

GENTZKOW, GD ;

SULLIVAN, JY .

AMERICAN JOURNAL OF CARDIOLOGY, 1984, 53 (05) :B101-B105

[7] FLECAINIDE-ASSOCIATED INTERSTITIAL PNEUMONITIS [J].

HANSTON, P ;

EVRARD, P ;

MAHIEU, P ;

WALLEMACQ, P ;

FRIOB, M ;

HASSOUN, A .

LANCET, 1991, 337 (8737) :371-372

[8] NONSPECIFIC INTERSTITIAL PNEUMONIA/FIBROSIS - HISTOLOGIC FEATURES AND CLINICAL-SIGNIFICANCE [J].

KATZENSTEIN, ALA ;

FIORELLI, RF .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1994, 18 (02) :136-147

[9] Idiopathic pulmonary fibrosis - Clinical relevance of pathologic classification [J].

Katzenstein, ALA ;

Myers, JL .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (04) :1301-1315

[10] Development of nonspecific interstitial pneumonitis associated with long-term treatment of primary pulmonary hypertension with prostacyclin [J].

Kesten, S ;

Dainauskas, J ;

McLaughlin, V ;

Rich, S .

CHEST, 1999, 116 (02) :566-569