A new generation of JASPAR, the open-access repository for transcription factor binding site profiles

被引：166

作者：

Vlieghe, Dominique

Sandelin, Albin

De Bleser, Pieter J.

Vleminckx, Kris

Wasserman, Wyeth W.

van Roy, Frans

Lenhard, Boris

机构：

[1] Univ Bergen, Bergen Ctr Computat Sci, Computat Biol Unit, N-5008 Bergen, Norway

[2] Univ Ghent VIB, Dept Mol Biomed Res, B-9052 Ghent, Belgium

[3] RIKEN, Yokohama Inst, RIKEN Genom Sci Ctr, Genome Explorat Res Grp,Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[4] Univ British Columbia, Dept Med Genet, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 1M9, Canada

来源：

NUCLEIC ACIDS RESEARCH | 2006年 / 34卷

关键词：

D O I：

10.1093/nar/gkj115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

JASPAR is the most complete open-access collection of transcription factor binding site (TFBS) matrices. In this new release, JASPAR grows into a meta-database of collections of TFBS models derived by diverse approaches. We present JASPAR CORE-an expanded version of the original, non-redundant collection of annotated, high-quality matrix-based transcription factor binding profiles, JASPAR FAM-a collection of familial TFBS models and JASPAR phyloFACTS-a set of matrices computationally derived from statistically overrepresented, evolutionarily conserved regulatory region motifs from mammalian genomes. JASPAR phyloFACTS serves as a non-redundant extension to JASPAR CORE, enhancing the overall breadth of JASPAR for promoter sequence analysis. The new release of JASPAR is available at http://jaspar.genereg.net.

引用

收藏

页码：D95 / D97

页数：3

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