Antibacterial use and Streptococcus pneumoniae penicillin resistance:: A temporal relationship model

被引:20
作者
Mera, Robertino M.
Miller, Linda A.
White, Anthony
机构
[1] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA
[2] GlaxoSmithKline, Collegeville, PA USA
关键词
D O I
10.1089/mdr.2006.12.158
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The nature of the temporal relationship between antibacterial consumption and Streptococcus pneumoniae penicillin resistance is investigated using population level data across time. IMS Health Global Services provided national outpatient antibiotic prescription data for the years 1996-2003 from France, Spain, Italy, Germany, the United Kingdom, and the United States. Surveillance data consist of S. pneumoniae isolates obtained from a surveillance database in the same geographic regions from 1996 to 2003. A linear mixed model for repeated measures was used to analyze the association between resistance and several antibacterial classes through time. Changes in penicillin resistance through time in any country are better explained by the weighted cumulative antibacterial consumption with a 2-year lag. Narrow-spectrum penicillins are associated with lower resistance rates. Large reductions in consumption at the population level are needed to affect resistance. There is a peak level of penicillin resistance associated with cumulative exposure to a combination of antibiotic classes that is unique for every country.
引用
收藏
页码:158 / 163
页数:6
相关论文
共 23 条
[11]   Outpatient antibiotic prescriptions from 1992 to 2001 in The Netherlands [J].
Kuyvenhoven, MM ;
van Balen, FAM ;
Verheij, TJM .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (04) :675-678
[12]   The population dynamics of antimicrobial chemotherapy [J].
Lipsitch, M ;
Levin, BR .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (02) :363-373
[13]   Frequency of penicillin-resistant pneumococci in children is correlated to community utilization of antibiotics [J].
Melander, E ;
Ekdahl, K ;
Jönsson, G ;
Mölstad, S .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2000, 19 (12) :1172-1177
[14]   Predicting the future Streptococcus pneumoniae resistance landscape [J].
Mera, R .
CURRENT OPINION IN PHARMACOLOGY, 2005, 5 (05) :459-464
[15]   Effect of β lactam antibiotic use in children on pneumococcal resistance to penicillin:: prospective cohort study [J].
Nasrin, D ;
Collignon, PJ ;
Roberts, L ;
Wilson, EJ ;
Pilotto, LS ;
Douglas, RM .
BRITISH MEDICAL JOURNAL, 2002, 324 (7328) :28-30A
[16]   Application of the ATC/DDD methodology to monitor antibiotic drug use [J].
Natsch, S ;
Hekster, YA ;
de Jong, R ;
Heerdink, ER ;
Herings, RMC ;
van der Meer, JWM .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1998, 17 (01) :20-24
[17]  
*NCCLS, 1997, M7A4 NCCLS, V17
[18]  
[NCCLS] National Committee for Clinical Laboratory Standards, 2002, M100S12 NCCLS
[19]   IN-VITRO SELECTIVE ANTIBIOTIC CONCENTRATIONS OF BETA-LACTAMS FOR PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE POPULATIONS [J].
NEGRI, MC ;
MOROSINI, MI ;
LOZA, E ;
BAQUERO, F .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (01) :122-125
[20]   In vitro selection of resistance to four β-lactams and azithromycin in Streptococcus pneumoniae [J].
Pankuch, GA ;
Jueneman, SA ;
Davies, TA ;
Jacobs, MR ;
Appelbaum, PC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (11) :2914-2918