Antiplasmodial activity of labdanes from Aframomum latifolium and Aframomum sceptrum

被引：27

作者：

Duker-Eshun, G

Jaroszewski, JW

Asomaning, WA

Oppong-Boachie, F

Olsen, CE

Christensen, SB

机构：

[1] Royal Danish Sch Pharm, Dept Med Chem, DK-2100 Copenhagen, Denmark

[2] Univ Ghana, Dept Chem, Legon, Accra, Ghana

[3] Ctr Sci Res Plant Med, Mampong Akwapim, Ghana

[4] Royal Vet & Agr Univ, Dept Chem, DK-1871 Frederiksberg, Denmark

来源：

PLANTA MEDICA | 2002年 / 68卷 / 07期

关键词：

D O I：

10.1055/s-2002-32888

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioguided fractionation of extracts of Aframomum, latifolium and A. sceptrum (Zingiberaceae) resulted in isolation of (+)-(S)-nerolidol and seven labdanes, coronarin B, galanal A and B, galanolactone, (E)-8beta,17-epoxylabd-12-ene-15,16-dial, (+)-(E)-labda-8(17), 12-diene-15,16-dial and its diethyl acetal, the latter being presumably an isolation artefact, The labdanes show a modest in vitro activity against a chloroquine-sensitive Plasmodium falciparum strain.

引用

页码：642 / 644

页数：3

共 19 条

[1]

Abbiw DK., 1990, Useful Plants of Ghana

[2]

Adegoke GO, 1998, FLAVOUR FRAG J, V13, P349, DOI [10.1002/(SICI)1099-1026(1998090)13:5<349::AID-FFJ758>3.0.CO

[3]

2-O, 10.1002/(SICI)1099-1026(1998090)13:5&lt

[4]

349::AID-FFJ758&gt