Ligand tuning in the chromium-salen-mediated asymmetric epoxidation of alkenes

被引：40

作者：

McGarrigle, EM ^{[1
]}

Murphy, DM ^{[1
]}

Gilheany, DG ^{[1
]}

机构：

[1] Univ Coll Dublin, Ctr Synth & Chem Biol, Conway Inst Biomol & Biomed Sci, Dept Chem, Dublin 4, Ireland

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 08期

关键词：

D O I：

10.1016/j.tetasy.2004.03.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of Cr(salen) complexes have been synthesised from 5-substituted-3-bromosalicylaldehydes and trans-1,2-cyclohexanediamine. These have been used to probe the Cr(salen)-mediated asymmetric epoxidation of alkenes. No simple correlation was found between the electronic character of the salen-substituents and the enantioselectivity-multiple oxidation pathways are proposed as a possible explanation. Enantioselectivities of Lip to 90% have been achieved using a novel, synthetically accessible Cr(salen) complex. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1343 / 1354

页数：12

共 66 条

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