Ameliorating effect of capsaicin on alterations in lipid metabolism during mice lung carcinoma

被引：8

作者：

Anandakumar, P. ^{[1
]}

Jagan, S. ^{[1
]}

Kamaraj, S. ^{[1
]}

Ramakrishnan, G. ^{[1
]}

Clara, J. Binu ^{[1
]}

Pathitha, D. ^{[1
]}

Kavitha, T. ^{[1
]}

Devaki, T. ^{[1
]}

机构：

[1] Univ Madras, Dept Biochem, Madras 600025, Tamil Nadu, India

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2009年 / 32卷 / 02期

关键词：

Capsaicin; Lung cancer; Lipids; Lipoproteins; Lipid metabolizing enzymes; RAT COLON CARCINOGENESIS; BREAST-CANCER PATIENTS; BENEFICIAL INFLUENCE; SEQUENTIAL-CHANGES; SERUM-LIPIDS; PEROXIDATION; ANTIOXIDANT; CHOLESTEROL; TAMOXIFEN; ENZYMES;

D O I：

10.1007/s12272-009-1140-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Spices and vegetables possess antioxidant activity that can be applied for preservation of lipids and lower lipid peroxidation in biological systems. In the present study, we have investigated the effect of capsaicin on lipid metabolism during benzo(a)pyrene induced lung cancer in Swiss albino mice. Benzo(a)pyrene (50 mg/kg wt) induced lung cancer animals showed abnormal changes in the tissue and serum lipids, lipoproteins and lipid metabolizing enzymes. Treatment with capsaicin (10 mg/kg body wt) remarkably attenuated all the above alterations and restored normalcy. These findings reveal the chemomodulatory potential of capsaicin in attenuating the alterations in lipid metabolism during experimental lung carcinogenesis.

引用

页码：229 / 234

页数：6

共 37 条

[1] Stabilization of pulmonary mitochondrial enzyme system by capsaicin during benzo(a)pyrene induced experimental lung cancer [J].

Anandakumar, P. ;

Kamaraj, S. ;

Jagan, S. ;

Ramakrishnan, G. ;

Vinodhkumar, R. ;

Devaki, T. .

BIOMEDICINE & PHARMACOTHERAPY, 2008, 62 (06) :390-394

[2] Beneficial influence of capsaicin on lipid peroxidation, membrane-bound enzymes and glycoprotein profile during experimental lung carcinogenesis [J].

Anandakumar, P. ;

Jagan, S. ;

Kamaraj, S. ;

Ramakrishnan, G. ;

Titto, A. A. ;

Devaki, T. .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2008, 60 (06) :803-808

[3] Capsaicin modulates pulmonary antioxidant defense system during benzo(a)pyrene-induced lung cancer in Swiss albino mice [J].

Anandakumar, P. ;

Kamaraj, S. ;

Jagan, S. ;

Ramakrishnan, G. ;

Vinodhkumar, R. ;

Devaki, T. .

PHYTOTHERAPY RESEARCH, 2008, 22 (04) :529-533

[4]

BIER M, 1955, METHOD ENZYMOL, V1, P631

[5]

Chowdhury B, 1996, MED SCI RES, V24, P669

[6] Ethanol fraction of Aralia elata Seemann enhances antioxidant activity and lowers serum lipids in rats when administered with benzo(α)pyrene [J].

Chung, CK ;

Jung, NE .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2003, 26 (10) :1502-1504

[7] CAPSAICIN - IDENTIFICATION, NOMENCLATURE, AND PHARMACOTHERAPY [J].

CORDELL, GA ;

ARAUJO, OE .

ANNALS OF PHARMACOTHERAPY, 1993, 27 (03) :330-336

[8] CAPSAICIN ACTION MODULATES LIPID-PEROXIDATION INDUCED BY DIFFERENT IRRITANTS [J].

DE, AK ;

GHOSH, JJ .

PHYTOTHERAPY RESEARCH, 1993, 7 (04) :273-277

[9] HYPERLIPIDEMIA IN CORONARY HEART-DISEASE .1. LIPID-LEVELS IN 500 SURVIVORS OF MYOCARDIAL-INFARCTION [J].

GOLDSTEIN, JL ;

HAZZARD, WR ;

SCHROTT, HG ;

BIERMAN, EL ;

MOTULSKY, AG .

JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (07) :1533-1543

[10] Hypercholesterolemia in rats with hepatomas: Increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol [J].

Hirayama, Takeshi ;

Honda, Akira ;

Matsuzaki, Yasushi ;

Miyazaki, Teruo ;

Ikegami, Tadashi ;

Doy, Mikio ;

Xu, Guorong ;

Lea, Michael ;

Salen, Gerald .

HEPATOLOGY, 2006, 44 (03) :602-611

← 1 2 3 4 →